Tuesday, May 30, 2006

Julius Axelrod

Let's talk about a genius instead of the gentleman from Mansfield Ohio.

Julius Axelrod (May 30, 1912 – December 29 2004) was an influential American biochemist.

He won a share of the Nobel Prize in Physiology or Medicine in 1970 along with Bernard Katz and Ulf von Euler.

The Nobel Committee honored him for his work on the release and reuptake of catecholamine neurotransmitters, a class of chemicals in the brain that include epinephrine, norepinephrine, and, as was later discovered, dopamine.

Axelrod also made major contributions to the understanding of the pineal gland and how it regulates the sleep-wake cycle. Early life and educationAxelrod was born in New York City, the son of Jewish immigrants from Poland. He received his bachelor's degree in biology from the College of the City of New York in 1933. Axelrod wanted to become a physician, but was rejected from every medical school to which he applied. He worked briefly as a laboratory technician at New York University, then in 1935 he got a job with the New York City Department of Health testing vitamin supplements added to food.

He injured his left eye when an ammonia bottle in the lab exploded; he would wear an eyepatch for the rest of his life. While working at the Department of Health, he attended night school and received his master's in sciences degree from New York University in 1941. ResearchAnalgesic research.

In 1946, Axelrod took a position working under Bernard Brodie at Goldwater Memorial Hospital. The research experience and mentorship Axelrod received from Brodie would launch him on his research career. Brodie and Axelrod's research focused on how analgesics (pain-killers) work. During the 1940s, users of non-aspirin analgesics were developing a blood condition known as methemoglobinemia. Axelrod and Brodie discovered that acetanilide, the main ingredient of these pain-killers, was to blame, and recommended replacement with acetaminophen (paracetamol), better known as Tylenol.
Catecholamine research

Julius Axelrod working at the blackboard on the structure of catecholaminesIn 1949, Axelrod began work at the National Heart Institute, part of the National Institutes of Health (NIH). At the National Heart Institute, he worked on the mechanisms and effects of caffeine, which led him to an interest in the sympathetic nervous system and its main neurotransmitters, epinephrine and norepinephrine. During this time, Axelrod also conducted research on codeine, morphine, methamphetamine, and ephedrine and performed some of the first experiments on LSD.

Realizing that he could not advance his career without a Ph.D., he took a leave of absence from the NIH in 1954 to attend George Washington University. Allowed to submit some of his previous research toward his degree, he graduated one year later, in 1955. Axelrod then returned to the NIH and began some of the key research of his career.

Axelrod received his Nobel Prize for his work on the release, reuptake and storage of the neurotransmitters epinephrine and norepinephrine, also known as adreniline and noradreniline. Working on monoamine oxidase (MAO) inhibitors in 1957, Axelrod showed that catecholamine neurotransmitters do not merely stop working after they are released into the synapse. Instead, neurotransmitters are recaptured (reuptaken) by the pre-synaptic nerve ending, and recycled for later transmissions. He theorized that epinephrine is held in tissues in an inactive form and is liberated by the nervous system when needed. This research laid the groundwork for later selective serotonin reuptake inhibitors (SSRIs), such as Prozac, which block the reuptake of another neurotransmitter, seretonin.

In 1958, Axelrod also discovered and characterized the enzyme catechol-O-methyl transferase, which is involved in the breakdown of catecholamines.

Axelrod's later research focused on the pineal gland. He and his colleagues showed that melatonin has profound effects on the central nervous system, allowing the pineal gland to act as a biological clock. He proved that melatonin is a converted form of the neurotransmitter serotonin and that the pineal gland regulates the release of serotonin to drive the body's circadian rhythm. He continued to work at the NIH until his retirement in 1984.

This gentleman provided us with a couple of medical breakthroughs that possibly affect us all. Tylenol has proved to be an effective pain reliever for children, infants and people with allergies to asprin. Virtually all depression medications are seratonin reuptake inhibitors.

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